Nuclear reprogramming and pluripotency

Tipo de material: Texto

TextoSeries ; Nature, 441, p.1061-1067, 2006Trabajos contenidos:

Hochedlinger, K
Jaenisch, R

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Resumen: The cloning of mammals from differentiated donor cells has refuted the old dogma that development is an irreversible process. It has demonstrated that the oocyte can reprogramme an adult nucleus into an embryonic state that can direct development of a new organism. The prospect of deriving patient-specific embryonic stem cells by nuclear transfer underscores the potential use of this technology in regenerative medicine. The future challenge will be to study alternatives to nuclear transfer in order to recapitulate reprogramming in a Petri dish without the use of oocytes.

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Documentos solicitados	CICY Documento préstamo interbibliotecario	Ref1	B-12703 (Browse shelf(Opens below))	Available

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Previous	B-12700 Chromatin dynamics in plants	B-12701 Cytosine methylation is associated with RNA silencing in silenced plants but not with systemic and transitive RNA silencing through grafting	B-12702 Dynamics of DNA Methylation in Chestnut Trees Development	B-12703 Nuclear reprogramming and pluripotency	B-12704 Epigenetic regulation of flowering	B-12705 Chromatin rearrangements in development	B-12706 Convergent evolution of genomic mprinting in plants and mammals	Next

The cloning of mammals from differentiated donor cells has refuted the old dogma that development is an irreversible process. It has demonstrated that the oocyte can reprogramme an adult nucleus into an embryonic state that can direct development of a new organism. The prospect of deriving patient-specific embryonic stem cells by nuclear transfer underscores the potential use of this technology in regenerative medicine. The future challenge will be to study alternatives to nuclear transfer in order to recapitulate reprogramming in a Petri dish without the use of oocytes.

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