Nanoparticles with entrapped á-tocopherol: synthesis, characterization, and controlled release

Tipo de material: Texto

TextoSeries ; Nanotechnology, 19(10), p.105606, 2008Trabajos contenidos:

Zigoneanu, I.G
Astete, C.E
Sabliov, C.M

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Resumen: An emulsion evaporation method was used to synthesize spherical poly(DL-lactide-co-glycolide)(PLGA)nanoparticles with entrapped á-tocopherol. Two different surfactants were used: sodium dodecyl sulfate (SDS)and poly(vinyl alcohol)(PVA). For SDS nanoparticles, the size of the nanoparticles decreased significantly with the entrapment of á-tocopherol in the PLGA matrix, while the size of PVA nanoparticles remained unchanged. The polydispersity index after synthesis was under 0.100 for PVA nanoparticles and around 0.150 for SDS nanoparticles. The zeta potential was negative for all PVA nanoparticles. The entrapment efficiency of á-tocopherol in the polymeric matrix was approximately 89

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An emulsion evaporation method was used to synthesize spherical poly(DL-lactide-co-glycolide)(PLGA)nanoparticles with entrapped á-tocopherol. Two different surfactants were used: sodium dodecyl sulfate (SDS)and poly(vinyl alcohol)(PVA). For SDS nanoparticles, the size of the nanoparticles decreased significantly with the entrapment of á-tocopherol in the PLGA matrix, while the size of PVA nanoparticles remained unchanged. The polydispersity index after synthesis was under 0.100 for PVA nanoparticles and around 0.150 for SDS nanoparticles. The zeta potential was negative for all PVA nanoparticles. The entrapment efficiency of á-tocopherol in the polymeric matrix was approximately 89

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