Image from Google Jackets

Flavonoids and the inhibition of PKC and PI 3-kinase

Tipo de material: TextoTextoSeries ; General Pharmacology, 32(3), p.279-286, 1999Trabajos contenidos:
  • Gamet-Payrastre, L
  • Manenti, S
  • Gratacap, M
  • Tulliez, J
  • Chap, H
  • Payrastre, B
Recursos en línea: Resumen: Flavonoids provide a large number of interesting natural compounds that are consumed daily and exhibit more or less potent and selective effects on some signaling enzymes as well as on the growth and proliferation of certain malignant cells in vitro. Among the identified signal transducers, phosphoinositide 3-kinase (PI 3-kinase)and protein kinase C (PKC)are now considered key players in many cellular responses including cell multiplication, apoptosis, and transformation. Despite their lack of strict specificity, some flavonoids provide valuable bases for the design of analogues that could be used to specifically block particular isoforms of PI 3-kinase or PKC and their downstream-dependent cellular responses. Ó 1999 Elsevier Science Inc. All rights reserved.
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Collection Call number Status Date due Barcode
Documentos solicitados Documentos solicitados CICY Documento préstamo interbibliotecario Ref1 B-13806 (Browse shelf(Opens below)) Available

Flavonoids provide a large number of interesting natural compounds that are consumed daily and exhibit more or less potent and selective effects on some signaling enzymes as well as on the growth and proliferation of certain malignant cells in vitro. Among the identified signal transducers, phosphoinositide 3-kinase (PI 3-kinase)and protein kinase C (PKC)are now considered key players in many cellular responses including cell multiplication, apoptosis, and transformation. Despite their lack of strict specificity, some flavonoids provide valuable bases for the design of analogues that could be used to specifically block particular isoforms of PI 3-kinase or PKC and their downstream-dependent cellular responses. Ó 1999 Elsevier Science Inc. All rights reserved.

There are no comments on this title.

to post a comment.