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Verticilide, a new ryanodine-binding inhibitor, produced byVerticilliumsp. FKI-1033

Tipo de material: TextoTextoSeries ; The Journal of Antibiotics , 63(2), p.77-82, 2010Trabajos contenidos:
  • Kazuro Shiomi
  • Ryosuke Matsui
  • Atsuo Kakei
  • Yuichi Yamaguchi
  • Rokuro Masuma
  • Hiroko Hatano
  • Noriko Arai
  • Noriko Arai
  • Haruo Tanaka
  • Susumu Kobayashi
  • Andreas Turberg
  • Satoshi Omura
Tema(s): Recursos en línea: Resumen: A new ryanodine-binding inhibitor, verticilide, was isolated from the cultured broth of a fungus,Verticilliumsp. FKI-1033. It is a 24-membered ring cyclic depsipeptide, its structure being elucidated as cyclo[(2R)-2-hydroxyheptanoyl-N-methyl-L-alanyl]4. Verticilide inhibited ryanodine binding to ryanodine receptors in the cockroach at an IC50value of 4.2lM, whereas inhibition against mouse ryanodine receptors was weak (IC50¼53.9lM).
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A new ryanodine-binding inhibitor, verticilide, was isolated from the cultured broth of a fungus,Verticilliumsp. FKI-1033. It is a 24-membered ring cyclic depsipeptide, its structure being elucidated as cyclo[(2R)-2-hydroxyheptanoyl-N-methyl-L-alanyl]4. Verticilide inhibited ryanodine binding to ryanodine receptors in the cockroach at an IC50value of 4.2lM, whereas inhibition against mouse ryanodine receptors was weak (IC50¼53.9lM).

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