Notch signalling: a simple pathway becomes complex

Tipo de material: Texto

TextoSeries ; Nature Review Molecular cell Biology, 7(9), p.678-689, 2006Trabajos contenidos:

Bray, S.J

Recursos en línea:

Para ver el documento ingresa a Google con tu cuenta: @cicy.edu.mx

Resumen: A small number of signalling pathways are used iteratively to regulate cell fates, cell proliferation and cell death in development. Notch is the receptor in one such pathway, and is unusual in that most of its ligands are also transmembrane proteins; therefore signalling is restricted to neighbouring cells. Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.

Tags from this library: No tags from this library for this title. Log in to add tags.

Average rating: 0.0 (0 votes)

Holdings
Item type	Current library	Collection	Call number	Status	Date due	Barcode
Documentos solicitados	CICY Documento préstamo interbibliotecario	Ref1	B-15577 (Browse shelf(Opens below))	Available

Browsing CICY shelves, Shelving location: Documento préstamo interbibliotecario, Collection: Ref1 Close shelf browser (Hides shelf browser)

Previous	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	No cover image available	Next
Previous	B-15574 Harmony among endemic littoral plants and adjacent floras in Israel	B-15575 Morfología polínica de las Cucurbitaceae de la Península de Yucatán, México	B-15576 Guinea yams the botany, ethnobotany, use and possible future of yams in West Africa	B-15577 Notch signalling: a simple pathway becomes complex	B-15578 Chemical regulation and the hormone concept	B-15579 Sequencing 5-methylcytosine residues by the bisulphite method	B-1558 IOPB chromosome number reports	Next

A small number of signalling pathways are used iteratively to regulate cell fates, cell proliferation and cell death in development. Notch is the receptor in one such pathway, and is unusual in that most of its ligands are also transmembrane proteins; therefore signalling is restricted to neighbouring cells. Although the intracellular transduction of the Notch signal is remarkably simple, with no secondary messengers, this pathway functions in an enormous diversity of developmental processes and its dysfunction is implicated in many cancers.

There are no comments on this title.

to post a comment.