Am I ready for CRISPR? A user's guide to genetic screens

Tipo de material: Texto

TextoSeries ; Nature Reviews Genetics, doi:10.1038/nrg.2017.97, 2017Trabajos contenidos:

Doench, John G

Tema(s):

CRISPR

Recursos en línea:

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Resumen: Exciting new technologies are often self-limiting in their rollout, as access to state-of-the-art instrumentation or the need for years of hands-on experience, for better or worse, ensures slow adoption by the community. CRISPR technology, however, presents the opposite dilemma, where the simplicity of the system enabled the parallel development of many applications, improvements and derivatives, and new users are now presented with an almost paralyzing abundance of choices. This Review intends to guide users through the process of applying CRISPR technology to their biological problems of interest, especially in the context of discovering gene function at scale.

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Item type	Current library	Collection	Call number	Status	Date due	Barcode
Documentos solicitados	CICY Documento préstamo interbibliotecario	Ref1	B-16778 (Browse shelf(Opens below))	Available

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Previous	B-16775 Genome Engineering and Agriculture: Opportunities and Challenges	B-16776 Gene Editing With TALEN and CRISPR/Cas in Rice	B-16777 Use of CRISPR/Cas9 for Crop Improvement in Maize and Soybean	B-16778 Am I ready for CRISPR? A user's guide to genetic screens	B-16779 CRISPR History: Discovery, Characterization, and Prosperity	B-1678 In Vitro Propagation of Grape	B-16780 On Improving CRISPR for Editing Plant Genes: Ribozyme-Mediated Guide RNA Production and Fluorescence-Based Technology for Isolating Transgene-Free Mutants Generated by CRISPR	Next

Exciting new technologies are often self-limiting in their rollout, as access to state-of-the-art instrumentation or the need for years of hands-on experience, for better or worse, ensures slow adoption by the community. CRISPR technology, however, presents the opposite dilemma, where the simplicity of the system enabled the parallel development of many applications, improvements and derivatives, and new users are now presented with an almost paralyzing abundance of choices. This Review intends to guide users through the process of applying CRISPR technology to their biological problems of interest, especially in the context of discovering gene function at scale.

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