Green synthesis of silver nanoparticles by using Simarouba amara aubl. Fruit extract and their antioxidant and antibacterial activities

The green synthesis of nanoparticles has emerged as a cost-effective and environmentally benign technique for therapeutic applications. Nanomedicine utilizes biocompatible nanomaterials for diagnostic and therapeutic potential for various biomedical applications. Different biological methods are gaining recognition over the physical and chemical methods of synthesis for the production of silver nanoparticles (AgNPs)due to their multiple applications. The present study describes the synthesis of AgNPs using the fruit extract of Simarouba amara (S. amara)followed by characterization of AgNPs was done using different methods, which include; ultraviolet-visible spectroscopy (UV-Vis)wherein it shows absorption peak at 410 nm confirming the AgNPs, from dynamic light scattering (DLS)the average particle size is 80nm with crystalline structure confirmed by scanning electron microscope (SEM)images and zeta potential analysis shows the positive polarity of the particle favoring the drug targeting. The powder X-ray diffraction study (PXRD)revealed crystalline nature with a face-centered cubic (fcc)structure of AgNPs. The synthesized AgNPs were also tested for antioxidant therein the particles could scavenge the stable free radical 1, 1-Diphenyl-2-picrylhydrazyl (DPPH)of about 80percent to that of positive control butylated hydroxytoluene (BHT)and antimicrobial studies indicated its microbicidal efficacy against both Gram positive and negative clinical pathogens. It could be concluded that Simarouba amara fruit extract can be used efficiently in the production of potential antioxidant and antimicrobial AgNPs for commercial application. © 2017, International Journal of Drug Delivery Technology.