Chemical constituents of Curcuma kwangsiensis and their antimigratory activities in RKO cells.

Tipo de material: Texto

TextoSeries ; Natural Product Research, 33(24), p.3493-3499, 2019Trabajos contenidos:

Wang, J. T
Ge, D
Qu, H. F
Wang, G. K
Wang, G

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Resumen: Two new sesquiterpenoids, curkwangsien A-B (1-2), and seven known compounds (3-9)were isolated from rhizomes of Curcuma kwangsiensis. Their structures were elucidated by spectroscopic analysis, and the absolute configurations of compounds 1-2 were determined by the quantum chemical ECD calculations. Compounds 3-9 are firstly reported from this plant. In the in vitro assays, compound 3 was found to inhibit human colon cancer RKO cell migration in time-dependent manner.

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Two new sesquiterpenoids, curkwangsien A-B (1-2), and seven known compounds (3-9)were isolated from rhizomes of Curcuma kwangsiensis. Their structures were elucidated by spectroscopic analysis, and the absolute configurations of compounds 1-2 were determined by the quantum chemical ECD calculations. Compounds 3-9 are firstly reported from this plant. In the in vitro assays, compound 3 was found to inhibit human colon cancer RKO cell migration in time-dependent manner.

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