Image from Google Jackets

N6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcription.

Tipo de material: TextoTextoSeries ; Science, 367(6477), p.580-586, 2020Trabajos contenidos:
  • Liu, J
  • Dou, X
  • Chen, C
  • Chen, C
  • Liu, C
  • Xu, M. M
  • He, C
Tema(s): Recursos en línea: Resumen: N6-methyladenosine (m6A)is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m6A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs)in mammalian cells. Disruption of m6A modification of these RNAs increases their abundance and promotes gene transcription by increasing the chromatin accessibility. Thus, m6A serves as a switch to regulate carRNA levels by tuning nearby chromatin state and downstream transcription.
Tags from this library: No tags from this library for this title. Log in to add tags.
Star ratings
    Average rating: 0.0 (0 votes)
Holdings
Item type Current library Collection Call number Status Date due Barcode
Documentos solicitados Documentos solicitados CICY Documento préstamo interbibliotecario Ref1 B-18136 (Browse shelf(Opens below)) Available

N6-methyladenosine (m6A)is the most abundant messenger RNA modification in almost all eukaryotes. Liu et al. now show that m6A is also cotranscriptionally added onto various chromosome-associated regulatory RNAs (carRNAs)in mammalian cells. Disruption of m6A modification of these RNAs increases their abundance and promotes gene transcription by increasing the chromatin accessibility. Thus, m6A serves as a switch to regulate carRNA levels by tuning nearby chromatin state and downstream transcription.

There are no comments on this title.

to post a comment.