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Bioactive cassane diterpenoids from the seeds of Caesalpinia sappan.

Tipo de material: TextoTextoSeries ; PhytoChemistry Letters, 22, p.113-116, 2017Trabajos contenidos:
  • Zhu, N. L
  • Xu, X. D
  • Hu, M. G
  • Sun, Z. H
  • Wu, T. Y
  • Yuan, J. Q
  • Ma, G. X
Tema(s): Recursos en línea: Resumen: Three new cassane-type diterpenoids named caesalppans G-I (1-3)together with three known ones (4-6), were isolated from the methanol extract of Caesalpinia sappan seeds. Their structures were determined based on spectroscopic data. Among the isolated compounds, compound 2 displayed a moderate antimalarial activity with an IC50 value of 2.4 ?M, and compound 4 showed mild anti-inflammatory activity with an IC50 value of 28.65 ?M.
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Three new cassane-type diterpenoids named caesalppans G-I (1-3)together with three known ones (4-6), were isolated from the methanol extract of Caesalpinia sappan seeds. Their structures were determined based on spectroscopic data. Among the isolated compounds, compound 2 displayed a moderate antimalarial activity with an IC50 value of 2.4 ?M, and compound 4 showed mild anti-inflammatory activity with an IC50 value of 28.65 ?M.

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