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Physically and chemically cross-linked cellulose cryogels: structure, properties and application for controlled release

Tipo de material: TextoTextoSeries ; Carbohydrate Polymers, 151, p.392-400, 2016Trabajos contenidos:
  • Ciolacu, Diana
  • Rudaz, Cyrielle
  • Vasilescu, Mihai
  • Budtova, Tatiana
Tema(s): Recursos en línea: Resumen: Porous cellulose matrices were prepared via cellulose dissolution in 8 wt percet NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated.
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Porous cellulose matrices were prepared via cellulose dissolution in 8 wt percet NaOH-water, physical gelation and chemical cross-linking with epichlorohydrin (ECH), coagulation in water and lyophilisation. Cellulose and cross-linker concentration were varied. The behaviour of gels upon coagulation and the swelling of cryogels in water were analysed. An anomalous high swelling at cross-linker concentration around stoichiometric molar ratio with cellulose was observed. Cellulose cryogel morphology, crystallinity and density were studied. The influence of chemical cross-linking on cellulose swelling was explained by suggesting that ECH acts as a spacer preventing cellulose chains tight packing during coagulation. Cellulose was loaded with a model drug, procaine hydrochloride, and the kinetics of its release was investigated.

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