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Identfication of new naphthalenones from Juglans mandshurica and evalution of their anticancer activities

Tipo de material: TextoTextoSeries ; Chinese Journal of Natural Medicines, 13(9), p.707-710, 2015Trabajos contenidos:
  • Li-Na, G. U. O
  • Zhang, R
  • Xue-Ying, G. U. O
  • Tao, C. U. I
  • Wei, D. O. N. G
  • Jin-Hai, H. U. O
  • Wei-Ming, W. A. N. G
Tema(s): Recursos en línea: Resumen: Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (1), 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (2). Compounds 1 and 2 were named as Juglanstetralone A (1)and Juglanstetralone B (2). Compound 1 showed more significant anti-tumor activity than 2 against gastric cancer BGC-823 cells, wih the IC50 of 125.89 (g(mL(-1).
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Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (1), 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (2). Compounds 1 and 2 were named as Juglanstetralone A (1)and Juglanstetralone B (2). Compound 1 showed more significant anti-tumor activity than 2 against gastric cancer BGC-823 cells, wih the IC50 of 125.89 (g(mL(-1).

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