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In tivo and in vitro degradation of poly( 3-hydroxybutyrate)in rat

Tipo de material: TextoTextoSeries ; BioMaterials, 12(3), p.309-312, 1991Trabajos contenidos:
  • Saito, T
  • Tomita, K
  • Juni, K
  • Ooba, K
Tema(s): Recursos en línea: Resumen: The inflammatory activity and biodegradation of poly(3-hydroxybutyrate)were examined. Poly (3-hydroxy-butyrate)sheet did not cause any inflammation in the chorioallantoic membrane of the developing egg. The i.v. injection of 14C-labelled poly(3-hydroxybutyrate)granules showed that 86, 2.5 and 2.4 percent of the total radioactivity administered were distributed in the liver, spleen and lung, respectively, and the radioactivity decreased slowly but steadily in most tissues examined during 2 month. Crude extracts of rat tissues showed that the activity degraded the poly(3-hydroxybutyrate)granules in vitro.
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The inflammatory activity and biodegradation of poly(3-hydroxybutyrate)were examined. Poly (3-hydroxy-butyrate)sheet did not cause any inflammation in the chorioallantoic membrane of the developing egg. The i.v. injection of 14C-labelled poly(3-hydroxybutyrate)granules showed that 86, 2.5 and 2.4 percent of the total radioactivity administered were distributed in the liver, spleen and lung, respectively, and the radioactivity decreased slowly but steadily in most tissues examined during 2 month. Crude extracts of rat tissues showed that the activity degraded the poly(3-hydroxybutyrate)granules in vitro.

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