The Multi-Pharmacological Targeted Role of Indole and its Derivatives: A review

Artículo

Heterocycles are a privileged motif that appears as a momentous objective in medicinal chemistry. An important class of compounds for drug discovery and design is indole and its derivatives, which have been examined for a variety of biological activities. Therefore, it is noteworthy in the modern progress of synthetic, medicinal chemistry; the last decade has been onlooker with a multitude of reports on several indole derivatives corroborating these chemical entities to be a renowned target for the discovery of new drugs. The current study includes brief natural sources of indole, and a new range of commercially available indole-based drugs. Additionally, this review discusses the numerous facets of the structure-activity relationship study (SARs) and provides information about the varied pharmacological effects of indole derivatives. The literature data presented for the anti-pharmacological agents herein covers largely from the year 2015 to mid of 2022.