DNA Methylation, Epigenetics and Metastasis [electronic resource] / edited by Manel Esteller.

How CpG Island Hypermethylation Leads to Cancer Dissemination: The Sounds of Silence for Tumor and Metastasis Suppressor Genes -- A Mouse Skin Multistage Carcinogenesis Model That Unmasks Epigenetic Lesions Responsible for Metastasis -- CpG Island Hypermethylation and Lung Cancer Invasion and Metastasis -- CpG Island Hypermethylation Changes during Prostate Cancer Progression and Metastasis -- CpG Island Hypermethylation in Breast Cancer Progression and Metastasis -- Epigenetic Dysregulation of Maspin (SerpinB5) in Cancer Invasion and Metastasis -- Epigenetic Regulation of the E-Cadherin Cell-Cell Adhesion Gene -- Epigenetic Disruption of the SLIT-ROBO Interactions in Human Cancer -- Molecular Mechanisms of the Metastasis-Associated Gene Family of Coregulators: Role in Cancer and Invasion -- The Molecular Mechanisms for Breast Cancer Metastasis Suppressor 1 Action in Cancer Metastasis -- Mechanisms of DNA Demethylating Drugs Against Cancer Progression -- Histone Deacetylase Inhibitors: Novel Targeted Anti-Cancer Agents.

This book provides a broad and rich outline of the epigenetic mechanisms involved in cancer progression and the generation of metastasis. It describes the tumor suppressor genes undergoing transcriptional silencing by CpG island promoter hypermethylation in the different tumor types of the human anatomy and their association with tumoral behaviour. It also provides a comprehensive insightful look at the molecular players involved in DNA methylation, histone modification and chromatin remodelling complexes causing epigenetic lesions linked to the metastasic phenotypes. Finally, it explains how epigenetic lesions associated with cancer spreading can be targeted using new and potent chemotherapy drugs. The book is a state-of-the-art reference to all scientific researchers and clinicians interested in the understanding of the biological processes leading to tumor dissemination and to those that are keen to translate this knowledge to a better management of cancer patients. Each contributor is a specialist in their epigenetic area and their joint effort has created a unique view of the DNA methylation, histone and chromatin changes that define cancer metastasis.