Proteases in Gastrointestinal Tissues [electronic resource] / edited by Uwe Lendeckel, Nigel M. Hooper.

Protease-Activated Receptors in Gastrointestinal Function and Disease -- Matrix Metalloproteinases in Gastric Cancer -- Proteases in Helicobacter pylori-Mediated Diseases -- Proteases in Pancreatic Disease -- PAR in the Pathogenesis of Pain in Pancreatic Disease -- Importance of the Local Renin-Angiotensin System in Pancreatic Disease -- Hepatitis C Viral Proteases And Inhibitors -- Angiotensin Converting Enzyme in the Pathophysiology of Liver Fibrosis -- Matrix Metalloproteinases in Chronic Liver Disease and Liver Transplantation -- MMPs and ADAMs in Inflammatory Bowel Disease -- Chemokines and Matrix Metalloproteinases in Colorectal Cancer -- Angiotensin-Converting Enzyme (ACE) in Gut Inflammation -- Intestinal Apical Protein Transport in Health and Disease.

This book is unique for its comprehensive presentation of protease function in stomach, colon, pancreas and liver under both physiological conditions and major diseases manifesting in these four organs. The individual chapters have been written by leaders in the field who paid much attention to outline in great detail the role of proteases in the pathogenesis, diagnosis and treatment of disease. Available animal models (of disease, transgenic, or knock-out) are extensively referred to and experimental data obtained thereby are discussed in the context of patient-derived data. Newcomers to the field and interested non-specialists will take advantage of the extensive introduction to individual proteases, protease families, and the diseases. Understanding is greatly facilitated by the clear and condensed presentation of summarised data in tables and graphs. This book is a valuable source for both clinicians and basic and clinical researchers interested in protease function and/or diseases in gastrointestinal tissues.