Chromatin and Disease [electronic resource] / edited by Tapas K. Kundu, R. Bittman, D. Dasgupta, H. Engelhardt, L. Flohe, H. Herrmann, A. Holzenburg, H-P. Nasheuer, S. Rottem, M. Wyss, P. Zwickl.

Chromatin Structure, Dynamics and Disease -- Structural Organization of Dynamic Chromatin -- ATP-dependent Chromatin Remodelling -- Regulation of Chromatin Structure and Chromatin-Dependent Transcription by Poly(Adp-Ribose) Polymerase-1 -- Histone Variant Nucleosomes -- Histone Variants and Complexes Involved in Their Exchange -- Histone Chaperones in Chromatin Dynamics -- Functions Of The Histone Chaperone Nucleolin In Diseases -- Chromatin as a Target for the DNA-Binding Anticancer Drugs -- Nonhistone Proteins, Sites for Epigenetic Marks: Link to Disease -- Reversible Acetylation Of Non Histone Proteins -- MARs and MARBPs -- Epigenetic Modifications of Chromatin: Implication in disease and therapeutics -- Aberrant Forms of Histone Acetyltransferases in Human Disease -- Chromatin Acetylation Status in the Manifestation of Neurodegenerative Diseases -- Functions of Myst Family Histone Acetyltransferases and Their Link to Disease -- Role Of Histone Phosphorylation In Chromatin Dynamics And Its Implications in Diseases -- Regulation And Function Of H3K9 Methylation -- Histone Acetylation And Methylation -- Chromatin-Associated Regulation Of Hiv-1 Transcription -- Small Molecule Modulators In Epigenetics.

The packaging of genomic DNA together with core histones, linker histones, and other functional proteins into chromatin play key roles in nuclear processes such as transcription, replication, repair and recombination. Research in the last two decades has unveiled the fact that many diseases involve an aberration of these processes at the chromatin level. Similarly, it is becoming clear that different processes such as chromatin assembly, remodeling of chromatin structure coupled to covalent modification of histone and non-histone proteins, chromatin modifying enzymes and last but not the least, important DNA-templated phenomena are the potential drug targets for diseases such as different types of cancer, neurodegenerrative diseases, AIDS etc. While, the earliest form of chemotherapy employed chromosomal DNA cleavage and modification, the study of epigenetic functions and therapy has recently emerged as a frontline research activity. At this juncture we felt the necessity to make an overview of the current research activities in the above areas. It is obvious that this collection starts with our current knowledge of chromatin structure. This work is the first endeavor to present different aspects encompassing the above theme.