Yeast as a Tool in Cancer Research [electronic resource] / edited by John L. Nitiss, Joseph Heitman.

From DNA Replication to Genome Instability in Schizosaccharomyces Pombe: Pathways to Cancer -- Dissecting Layers of Mitotic Regulation Essential for Maintaining Genomic Stability -- Yeast as a Tool in Cancer Research: Nuclear Trafficking -- Studies of Protein Farnesylation in Yeast -- From Bread to Bedside: What Budding Yeast has Taught us about the Immortalization of Cancer Cells -- HSP90 Co-Chaperones in Saccharomyces Cerevisiae -- Yeast as a Model System for Studying Cell Cycle Checkpoints -- Metabolism and Function of Sphingolipids in Saccharomyces Cerevisiae: Relevance to Cancer Research -- Exploring and Restoring the p53 Pathway Using the p53 Dissociator Assay in Yeast -- Functional Analysis of the Human p53 Tumor Suppressor and its Mutants Using Yeast -- ABC Transporters in Yeast - Drug Resistance and Stress Response in a Nutshell -- The FHCRC/NCI Yeast Anticancer Drug Screen -- Yeast as a Model to Study the Immunosuppressive and Chemotherapeutic Drug Rapamycin -- Use of Yeast as a Model System for Identifying and Studying Anticancer Drugs -- Genetic Analysis of Cisplatin Resistance in Yeast and Mammals -- Using Yeast Tools to Dissect the Action of Anticancer Drugs: Mechanisms of Enzyme Inhibition and Cell Killing by Agents Targeting DNA Topoisomerases.

Yeast is an experimental system that has led to critical discoveries in cell and molecular biology. The wide range of tools available in yeast has also made it an important system in many areas relevant to cancer including anti-cancer drug discovery, mechanisms of cell cycle control, and biological responses to stress. The present volume represents a state-of-the-art description of many areas of cancer research where yeast based systems are proving particularly valuable. This volume is of particular value to cancer researchers who lack extensive experience with yeast, but are interested in current results with this highly relevant experimental system.