Plant bioactives and drug discovery : principles, practice, and perspectives / edited by Valdir Cechinel Filho

Incluye referencias bibliográficas e índice

Contenido: Natural products in drug discovery : recents advances / Gordon M. Cragg, Paul G. Grothaus, David J. Newman -- Modern approaches in the search for new active compounds from crude extracts of natural sources / Emerson F. Queiroz, Kurt Hostettmann, Jean-Luc Wolfender -- Natural product as lead compounds in medicinal chemistry / Eliezer J. Barreiro, Carlos A.M. Fraga, Lidia M. Lima -- The importance of structural manipulation of natural compounds in drug discovery and development / Arturo San Feliciano ... [et al.] -- The action of plants and their constituents on the central nervous system / Fulvio R. Mendes ... [et al.] -- The role of natural products in discovery of new anti-infective agents with emphasis on antifungal compounds / Maximiliano Sortino ... [et al.] -- Antiulcer agents from higher plants / Luiz C. Klein-Junior, José R. Santin, Sérgio F. de Andrade -- Recent progress in the chemistry and biology of paclitaxel (Taxol) and related taxanes / Jun Qi, Jielu Zhao, David G.I. Kingston -- Cancer chemopreventive activity of higher plants / A. Douglas Kinghorn ... [et al.] -- Medicinal plants and pharmaceutical technology / Ruth M. Lucinda da Silva, Angélica G. Couto, Tania M.B. Bresolin -- Natural products in clinical trials / Sigrun Chrubasik -- The influence of biotic and abiotic factors on the production of secondary metabolites in medicinal plants / Dayana R. Gouveia, Leonardo Gobbo-Neto, Norberto P. Lopes -- Production of bioactives compounds : the importance of Pictet-Spengler reaction in the XXI century / Pilar Menendez ... [et al.] -- Screening methods for drug discovery from plants / Alan L. Harvey -- Phytotherapeutics: intellectual property rights, global market, and global regulatory guidelines / James D. McChesney, Raymond Cooper, Kip Vought -- Cooperation between the pharmaceutical industry and academic institutions in drug discovery / Valdir Cechinel Filho, Rivaldo Niero, and Rosendo A. Yunes

Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principies, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural producís, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural producís in clinical triáis, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural producís as drugs that target specific disease áreas, including neurological disorders, inflammation, infectious diseases, and cáncer, ¡Ilústrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields