TY  - BOOK
AU  - Clemons,K.V.
AU  - Miller,T.K.
AU  - Selitrennikoff,C.P.
AU  - Stevens,D.A.
TI  - fos-1, a putative histidine kinase as a virulence factor systemic aspergillosis
N2  - In fungi, two-component histidine kinases have various functions including regulation of osmosensitivity, and of cell-wall assembly. Furthermore, one of these proteins, cos-1, has been shown to be important for virulence of Candida albicans. Recently, a putative histidine kinase, fos-1, has been isolated and partially characterized from Aspergillus fumigatus. Here we compare the virulence of a fos-1 deletion strain with that of the parental wild-type strain in a murine model of systemic aspergillosis. Our results show that the fos-1 deletion strain has significantly reduced virulence as compared with the parental wild-type strain. Thus, we propose that the fos-1 two-component histidine kinase is a virulence factor of A. fumigatus
UR  - https://drive.google.com/file/d/1E-6hOCPPr5YmOLu3i1PEOpByM503LYip/view?usp=drivesdk
ER  -