TY  - BOOK
AU  - Firon,A.
AU  - d'Enfert,C.
TI  - Identifying essential genes in fungal pathogens of humans
KW  - CANDIDA ALBICANS
KW  - ASPERGILLUS FUMIGATUS
KW  - CRYPTOCOCCUS NEOFORMANS
KW  - ANTIFUNGAL TARGET
KW  - RNAI
KW  - GENE SILENCING
KW  - TRANSPOSON MUTAGENESIS
N2  - Opportunistic fungal pathogens are an important cause of fatal invasive diseases and one of the many threats facing immunocompromised patients. Because of the limitations of the antifungal therapies currently available such as their toxicity, their narrow spectrum and the emergence of resistant pathogens, there is a significant demand for a broader antifungal arsenal. The characterization of genes essential for fungal growth will be an important step in the identification and development of novel antifungal drugs. Original strategies and new technologies including in vivo or in vitro transposon mutagenesis and post-transcriptional gene silencing are being developed for genome-scale identification of essential genes in fungal species that are pathogenic to humans
UR  - https://drive.google.com/file/d/1CfA8Gdfoc9vPIPisWVqGaZYkse-R7ADQ/view?usp=drivesdk
ER  -