TY  - BOOK
AU  - Juvvadi,P.R.
AU  - Kuroki,Y.
AU  - Arioka,M.
AU  - Nakajima,H.
AU  - Kitamoto,K.
TI  - Functional analysis of the calcineurin-encoding gene cnaA from Aspergillus oryzae: evidence for its putative role in stress adaptation
KW  - ASPERGILLUS ORYZAE
KW  - STRESS
KW  - CALCINEURIN A
KW  - CNAA
KW  - PROTEIN PHOSPHATASE 2B
KW  - CALMODULIN- DEPENDENT PROTEIN PHOSPHATASE
N2  - The presence of putative STRE (stress response regulatory element)and HSF (heat-shock factor)transcription factor binding sites in the promoter region of the gene encoding calcineurin (cnaA)from Aspergillus oryzae implicated a probable role for calcineurin in the stress response. The activity of calcineurin was enhanced during growth of the wild-type strain in the presence of 1 M NaCl (2.6-fold), at alkaline pH 10.0 (2.9-fold)and at 37 °C (1.6-fold). The induction of cnaA antisense expression resulted in reduced calcineurin activity (1.4-fold)and caused a growth defect under the stress conditions. Induction of a strain overexpressing cnaA resulted in an increase in calcineurin activity under stress conditions, such as the presence of 1 M NaCl (73
UR  - https://drive.google.com/file/d/1Wzk4L9dS3iZSMA-2ZyW1QerQQnr8TCQ7/view?usp=drivesdk
ER  -