TY  - BOOK
AU  - Hughes,E.H.
AU  - Hong,S-B
AU  - Gibson,S.I.
AU  - Shanks,J.V.
AU  - San,K-Y.
TI  - Metabolic engineering of the indole pathway in Catharanthus roseus hairy roots and increased accumulation of tryptamine and serpentine
N2  - Transgenic hairy roots of Catharanthus roseus were established with glucocorticoid inducible tryptophan decarboxylase (TDC)expression alone or in combination with inducible expression of a feedback-resistant anthranilate synthase alpha subunit (AS)from Arabidopsis. Northern blot analysis confirmed transcription of the anthranilate synthase gene upon induction in the double line (TDC+AS)and in vitro enzyme assays confirmed increased resistance to feedback inhibition by tryptophan. In TDC enzyme assays, increases of 48
UR  - https://drive.google.com/file/d/1Ok9zVgwEM_Av9GFpvrSelcnNJmFWVZib/view?usp=drivesdk
ER  -