TY  - BOOK
AU  - Eigen,M.
TI  - The origin of genetic information: viruses as models
KW  - MOLECULAR EVOLUTION
KW  - SEQUENCE SPACE
KW  - ERROR THRESHOLD
KW  - SELECTION
KW  - QUASI-SPECIES
KW  - RNA VIRUSES
KW  - HYPERCYCLES
KW  - EVOLUTIONARY BIOTECHNOLOGY
N2  - living entity can be described as a complex adaptive system which differs from any, however complex, chemical structure by its capability of functional self-organization based on the processing of information. If one asks, where does this information come from and what is its primary semantics, the answer is: information generates itself in feedback loops via replication and selection, the objective being 'to be or not to be'. This paper describes the theoretical framework of information-generating systems and provides experimental clues for some basic forms of genetic organization, such as molecular quasi-species, hypercyclic and compartmentalized RNA-protein assemblies. The results are primarily obtained with RNA viruses and virus-like systems. The experiments are carried out with the help of automated, computer-controlled bioreactors, called 'evolution machines', that may form the basis of a new 'evolutionary biotechnology'
UR  - https://drive.google.com/file/d/1Ubml1kuamgHvHe49V4icPGM1onr-AIm8/view?usp=drivesdk
ER  -