TY  - BOOK
AU  - Ye,ChL.
AU  - Liu,J.W.
AU  - Wei,D.Z.
AU  - Lu,Y.H.
AU  - Qian,F.
TI  - In vivo antitumor activity by 2',4'-dihydroxy-6'-methoxy-3',5'-dimethylchalconein a solid human carcinoma xenograft model
KW  - CLEISTOCALYX OPERCULATUS
KW  - FLAVONOIDS
KW  - TUMOR
KW  - ACUTE TOXICITY
KW  - XENOGRAFT
N2  - Previously we have shown that 2¢,4¢-dihydroxy- 6'-methoxy-3',5'-dimethylchalcone (DMC), which is isolated from the buds of Cleistocalyx operculatus, significantly inhibits the growth of human liver cancer SMMC-7721 cells and is able to induce apoptosis of SMMC-7721 cells in vitro. Here we report the antitumor effects of DMC in vivo, using a solid human tumor xenograft mouse model using human liver cancer SMMC-7721 cells. The average tumor weights in the control group and in mice injected with 150 mg/kg DMC were 1.42±0.11 g and 0.59±0.12 g, respectively. Flow cytometric analysis of the tumor cell population demonstrated an aneuploid peak (representing 33.60±0.80
UR  - https://drive.google.com/file/d/13_g-qrqRpZ1rlfZqviOJoDqOddX--KvH/view?usp=drivesdk
ER  -