Development of a Simple Assay Protocol for High-Throughput Screening of Mycobacterium tuberculosis Glutamine Synthetase for the Identification of Novel Inhibitors 

 -  Journal of BioMolecular Screening, 10(7), p.725-729, 2005 .
<br/><br/> Mycobacterium tuberculosis glutamine synthetase (GS)is an essential enzyme involved in the pathogenicity of the organism. The screening of a compound library using a robust high-throughput screening (HTS)assay is currently thought to be the most efficient way of getting lead molecules, which are potent inhibitors for this enzyme. The authors have purified the enzyme to a >90 
<br/><br/><label>Subjects--Topical Terms: </label><br/>GLUTAMINE SYNTHETASE<br/>HIGH-THROUGHPUT SCREENING<br/>MYCOBACTERIUM