Antioxidant action of bixin against cisplatin-induced chromosome aberrations and lipid peroxidation in rats
- Pharmacological Research, 43, p.561-566, 2001 .
Cisplatin is one of the most active cytotoxic agents in the treatment of cancer, but has serious side effects, inducing nephrotoxicity and chromosome aberrations. In this study we evaluated the role of the carotenoid bixin on cisplatin-induced oxidative stress in Wistar rats through three markers of oxidative damage: chromosome aberrations, glutathione depletion and lipid peroxidation. The animals were divided into six treatment groups with six rats in each (n D6). The dose of cisplatin (5.0 mg kg..1 body wt.)was injected i.p. and bixin (2.5 or 5.0 mg kg..1 body wt.)was given by gavage at 48, 24 h and 10 min before the cisplatin injection. The treatment with the highest dose of bixin resulted in a statistically significant reduction, by about 33