A simple procedure for the solid phase synthesis of unsymmetrically functionalised diamides from symmetric diacids 

 -  Tetrahedron Letters, 40(2), p.235-238, 1996 .
<br/><br/> The solid phase synthesis of unsymmetrically substituted diamides from symmetric dicarboxylic acids is described. The process was conducted following these steps: (1)preactivation of the dicarboxylic acid with BOP, (2)addition to amine resin, (3)reaction with a second amine, and (4)TFA cleavage to afford the desired diamide. Most of the unsymmetric diamides were obtained in >80