TY  - BOOK
AU  - Chami,L.A.
AU  - Méndez,B
AU  - Chataing,B.
AU  - O'Callaghan,J.
AU  - Usubillaga,A
AU  - LaCruz,L.
TI  - Toxicological Effects of Alfa-Solamargine in Experimental Animals
KW  - SOLAMARGINE
KW  - SOLANACEAE
KW  - GLYCOALKALOIDS
KW  - TOXICOLOGY
KW  - PHARMACOLOGY
N2  - Alfa-Solamargine isolated from the fresh fruits of Solanum americanum Miller was studied for its toxicity. Lethality studies in rats showed a dose-mortality relationship with a LD50 of 42 mg/kg body weight intraperitoneally. The chronic and subchronic toxicity investigations indicated that the size of the glycoalkaloid dose was more important than the total glycoalkaloid intake. No appreciable toxic effects were observed at doses below 35 mg/kg body weight as indicated by blood parameters, enzyme levels and histological sections of kidney, liver and cardiac muscle. á-Solamargine did not affect the weight of the testes and epididymis or the number of spermatozoa but produced a slight irritation and congestion in the epididymis and testis at doses up to 50 mg/kg body weight
UR  - https://drive.google.com/file/d/1Vb2yxmzRfhqiaPi5h7XxHEdgZPLJl9xG/view?usp=drivesdk
ER  -