TY  - BOOK
AU  - Lall,N.
AU  - Das Sarma,M.
AU  - Hazra,B.
AU  - Meyer,J.J.M.
TI  - Antimycobacterial activity of diospyrin derivatives and a structural analogue of diospyrin against Mycobacterium tuberculosis in vitro
N2  - Three derivatives and one structural analogue of diospyrin were synthesized and investigated for their inhibitory activity against Mycobacterium tuberculosis employing the rapid radiometric method in vitro. A novel aminoacetate derivative was found to be more active than the parent compound, the MICs being 50 and 100 mg/L, respectively, for a drug-susceptible strain, H37Rv, of M. tuberculosis. This derivative also exhibited an MIC of 50 mg/L for a few multidrug-resistant strains of M. tuberculosis. The other two derivatives and the analogue did not show any significant antimycobacterial activity at the highest concentration (100 mg/L)tested
UR  - https://drive.google.com/file/d/1Wz4Bp0669oS4C5qAEjxhLXWXTLzrt8W4/view?usp=drivesdk
ER  -