Phytotoxins from the fungus Malbranchea aurantiaca 

 -  PhytoChemistry, 66(9), p.1012-1016, 2005 .
<br/><br/> Bioassay-directed fractionation of an ethyl acetate extract from cultures of the fungus Malbranchea aurantiaca led to the isolation of two phytotoxic compounds, namely, 1-hydroxy-2-oxoeremophil-1(10),7(11),8(9)-trien-12(8)-olide (1)and penicillic acid (2). The structure of 1 was established by spectroscopic and X-ray crystallographic analyses. Metabolites 1 and 2 caused significant inhibition of radicle growth of Amaranthus hypochondriacus with IC50 values 6.57 and 3.86 lM, respectively. In addition, 1 inhibited activation of the calmodulin-dependent enzyme cAMP phosphodiesterase (IC50 = 10.2 lM). 
<br/><br/><label>Subjects--Topical Terms: </label><br/>MALBRANCHEA AURANTIACA<br/>AMARANTHUS HYPOCHONDRIACUS<br/>EREMOPHILANE<br/>SESQUITERPENOIDS<br/>1-HYDROXY-2-OXOEREMOPHIL-1(10),7(11),8(9)-TRIEN-12(8)-OLIDE<br/>CALMODULIN<br/>CAMP PHOSPHODIESTERASE<br/>PHYTOTOXINS