TY  - BOOK
AU  - Martínez-Luis,S.
AU  - González,M.C.
AU  - Ulloa,M.
AU  - Mata,R.
TI  - Phytotoxins from the fungus Malbranchea aurantiaca
KW  - MALBRANCHEA AURANTIACA
KW  - AMARANTHUS HYPOCHONDRIACUS
KW  - EREMOPHILANE
KW  - SESQUITERPENOIDS
KW  - 1-HYDROXY-2-OXOEREMOPHIL-1(10),7(11),8(9)-TRIEN-12(8)-OLIDE
KW  - CALMODULIN
KW  - CAMP PHOSPHODIESTERASE
KW  - PHYTOTOXINS
N2  - Bioassay-directed fractionation of an ethyl acetate extract from cultures of the fungus Malbranchea aurantiaca led to the isolation of two phytotoxic compounds, namely, 1-hydroxy-2-oxoeremophil-1(10),7(11),8(9)-trien-12(8)-olide (1)and penicillic acid (2). The structure of 1 was established by spectroscopic and X-ray crystallographic analyses. Metabolites 1 and 2 caused significant inhibition of radicle growth of Amaranthus hypochondriacus with IC50 values 6.57 and 3.86 lM, respectively. In addition, 1 inhibited activation of the calmodulin-dependent enzyme cAMP phosphodiesterase (IC50 = 10.2 lM)
UR  - https://drive.google.com/file/d/1szppQnIS5zjhCfc9MoKxfViWgf4tMYrn/view?usp=drive_link
ER  -