TY  - BOOK
AU  - Bandyopadhyay,A.
AU  - Blakeslee,J.J.
AU  - Lee,O.R.
AU  - Mravec,J.
AU  - Sauer,M.
AU  - Titapiwatanakun,B.
AU  - Makam,S.N.
AU  - Makam,S.N.
AU  - Geisler,M.
AU  - Martinoia,E.
AU  - Friml,J.
AU  - Peer,W.A.
AU  - Murphy,A.S.
TI  - Interactions of PIN and PGP auxin transport mechanisms
N2  - Polarized transport of the plant hormone auxin influences multiple growth processes in plants and is regulated by plasma-membrane-localized efflux and uptake carriers. The PGP (P-glycoprotein)ABC transporters (ATP-binding-cassette transporters), PIN (pin-formed)subfamily of major facilitator proteins and members of AUX/LAX families have been shown to independently transport auxin both in planta and in heterologous systems. However, PIN- and PGP-mediated transport in heterologous systems exhibits decreased substrate specificity and inhibitor-sensitivity compared with what is seen in plants and plant cells. To determine whether PIN-PGP interactions enhance transport specificity, we analysed interactions of the representative auxin-transporting PGPs with PIN1 and AUX1 in planta and in heterologous systems. Here, we provide evidence that PINs and PGPs interact and function both independently and co-ordinately to control polar auxin transport and impart transport specificity and directionality. These interactions take place in protein complexes stabilized by PGPs in detergent-resistant microdomains
UR  - https://drive.google.com/file/d/1U-Pu22ngtBVr9MCXN4i9TSrGNY7rWCrH/view?usp=drivesdk
ER  -