TY  - BOOK
AU  - Pennings,A.J.
AU  - Knol,K.E.
AU  - Hoppen,H.J.
AU  - Leenslag,J.W.
AU  - van der Lei,B.
TI  - A two-ply artificial blood vessel of polyurethane and poly(L-lactide)
KW  - TWO-_PLY VASCULAR PROSTHESIS
KW  - BIODEGRADABLE
KW  - SALT-_LEACHING TECHNIQUE
KW  - CROSSLINKING
KW  - BLOODCOMPATIBLE
KW  - ANEURISM
N2  - A biodegradable microporous small-caliber vascular prosthesis has been developed that consists of two layers. The inner layer has been made highly antithrombogenic by cross-linking of a mixture of linoleic acid and an alipharic polyetherurethane with dicumylperoxide. Microporosity was introduced by adding sodiumfluoride crystals of about 5 I~m in diameter prior to cross-linking and leaching them out afterwards. The outer ply has been constructed by precipitating a (95/5)physical mixture ofpolyesterurethane and poly(L-lactide)from solution in the presence of sugar crystals with dimensions in the range 30-90 t~m which were removed by exposing the graft to water. The two-ply grafts were tested in vivo by replacing I cm of the abdominal aorta of rats. All the grafts remained patent at least up to 1 year and did not exhibit any aneurismal formarion. The inner layer was covered with endothelial cells and several layers of smooth muscle cells
UR  - https://drive.google.com/file/d/1DLrJDZMP4SQvQjvA9IFqA-pZmfA0qTQt/view?usp=drivesdk
ER  -