TY  - BOOK
AU  - Miller,A.T.
AU  - Sandberg,M.
AU  - Huang,Y.H.
AU  - Young,M.
AU  - Sutton,S.
AU  - Sauer,K.
AU  - Cooke,M.P.
TI  - Production of Ins(1,3,4,5)P4 mediated by the kinase Itpkb inhibits store-operated calcium channels and regulates B cell selection and activation
N2  - Antigen receptor-mediated production of inositol-1,4,5-trisphosphate (Ins(1,4,5)P3)in lymphocytes triggers the release of Ca2+ from intracellular stores; this release of Ca2+ results in the opening of store-operated Ca2+ channels in the plasma membrane. Here we report that mice lacking Ins(1,4,5)P3 3-kinase B (Itpkb), which converts Ins(1,4,5)P3 to inositol-1,3,4,5- tetrakisphosphate (Ins(1,3,4,5)P4), had impaired B lymphocyte development and defective immunoglobulin G3 antibody responses to a T lymphocyte-independent antigen. Itpkb-deficient B lymphocytes had the phenotypic and functional features of tolerant B lymphocytes and showed enhanced activity of store-operated Ca2+ channels after B lymphocyte receptor stimulation which was reversed by the provision of exogenous Ins(1,3,4,5)P4. Our data identify Itpkb and its product Ins(1,3,4,5)P4 as inhibitors of store-operated Ca2+ channels and crucial regulators of B cell selection and activation
UR  - https://drive.google.com/file/d/1AYqjXQ4yE-DLzvr_jDAlztsG89TPfrTn/view?usp=drivesdk
ER  -