Differential gene expression profiles in the hippocampus of senescence-accelerated mouse 

 -  NeuroBiology of Aging, 28(4), p.497-506, 2007 .
<br/><br/> The senescence-accelerated mouse (SAM)is an animal model for studying senescence and age-associated disorders due to its inherited aging phenotype. The SAM/prone8 (SAMP8)is a useful animal model to investigate the fundamental mechanisms involved in age-related learning and memory deficits that may have relevance to age-associated AD, while SAM/resistant1 (SAMR1)shows normal. To identify genes rendering the cognitive deterioration with aging, the subtractive cDNA libraries containing 1924 clones with the positive ratio of 96.18 
<br/><br/><label>Subjects--Topical Terms: </label><br/>SENESCENCE-ACCELERATED MOUSE<br/>ALZHEIMER'S DISEASE<br/>CDNA MICROARRAY