Betulinic Acid and Its Derivatives: A Review on their Biological Properties 

 -  Current Medicinal Chemistry, 12(6), p.657-666, 2005 .
<br/><br/> Betulinic acid is a naturally occurring pentacyclic triterpenoid and has been shown to exhibit a variety of biological activities including inhibition of human immunodeficiency virus (HIV), antibacterial, antimalarial, antiinflammatory, anthelmintic and antioxidant properties. This article reports a survey of the literature dealing with betulinic acid related biological properties that has appeared from the 1990's to the beginning of 2003. A broad range of medical and pharmaceutical disciplines are covered, including a brief introduction about discovery, phytochemical aspects, organic synthesis, anti-HIV and cytotoxic mechanisms of action. Various structural modifications carried out and their biological and pharmacokinetic profiles are also incorporated. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>BETULINIC ACID<br/>ANTI-HIV DERIVATIVES<br/>ANTI-HIV MECHANISM<br/>ANTICANCER DERIVATIVES<br/>ANTICANCER MECHANISM<br/>ANTIINFLAMMATORY<br/>ANTIMALARIAL<br/>BIOTRANSFORMATION