TY  - BOOK
AU  - Le Tien,C
AU  - Lacroix,M.
AU  - Ispas-Szabo,P.
AU  - Mateescu,Ma
TI  - N-acylated chitosan: hydrophobic matrices for controlled drug release
KW  - CHITOSAN
KW  - N-ACYLATION
KW  - HYDROPHOBIC SELF-ASSEMBLING
KW  - PALMITOYL CHITOSAN
KW  - CONTROLLED RELEASE
N2  - N-acylation of chitosan with various fatty acid (C6-C16)chlorides increased its hydrophobic character and made important changes in its structural features. Unmodified chitosan exhibited a low degree of order (DO)and a weak tablet crushing strength. Chitosan acylated with a short chain length (C6)possessed similar properties, but exhibited significant swelling. Acylation with longer side chains (C8-C16)resulted in a higher DO and crushing strength but lower swelling. The best mechanical characteristics and drug release properties were found for palmitoyl chitosan (substitution degree 40-50
UR  - https://drive.google.com/file/d/16_5ifnVIJnw09hL0K3af0qofjUmFKs1w/view?usp=drivesdk
ER  -