TY  - BOOK
AU  - Haoyun An
AU  - Zhu,J.
AU  - Wang,X.
AU  - Xu,X.
TI  - Synthesis and anti-tumor evaluation of new trisulfide derivatives
N2  - New bis-aromatic and heterocyclic trisulfide derivatives 5, 7-10 were synthesized by optimizing lead dibenzyl trisulfide natural product (4)to evaluate their anti-tumor activities. Five compounds 5-7, 9, and 10 exhibited potent anti-tumor activities against eight different tumor cell lines with low cytotoxicity against HepG2. Initial SAR was discussed, and MOA of these anti-microtubule agents was suggested based on cell kinetic response patterns observed on RT-CES system
UR  - https://drive.google.com/file/d/1fdRAxV2AzLjYfO_3eRKb1wV5A-_cOWXd/view?usp=drivesdk
ER  -