Synthesis and Pharmacological Activity of Betulin Dinicotinate 

 -  Russian Journal of Bioorganic Chemistry, 28, p.543-550, 2002 .
<br/><br/> The assignment of NMR resonances of lupane triterpenoids was refined by the example of 3 O ,28 O - dinicotinoylbetulin, obtained by acylation of betulin. Hepatoprotective, antiulcer, antiinflammatory, reparative, and anti-HIV activities were found for the compound. In addition, it was demonstrated to have immunomodulatory activity, for the first time detected among lupane triterpenoids. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>BETULIN DINICOTINATE<br/>HEPATOPROTECTIVE<br/>IMMUNOMODULATORY<br/>ANTIULCER<br/>ANTI-HIV ACTIVITIES<br/>LUPANE TRITERPENOIDS