TY  - BOOK
AU  - Nagai,T.
AU  - Miyaichi,Y.
AU  - Tomimori,T.
AU  - Suzuki,Y.
AU  - Yamada,H.
TI  - In vivo anti-influenza virus activity of plant flavonoids possessing inhibitory activity for influenza virus sialidase
KW  - INFLUENZA VIRUS
KW  - SIALIDASE
KW  - NEURAMINIDASE
KW  - FLAVONOID
N2  - Isoscutellarein (5,7,8,4'-tetrahydroxyflavone)from the leaf of Scutellaria baicalensis non-competitively inhibited (IC50, 20 pM)the hydrolysis of sodium p-nitrophenyl-N-acetyl-a-D-neuraminate by influenza virus sialidase with an apparent Ki value of 41 #M. Negligible inhibitory activity was observed for mouse liver sialidase at a concentration of 79 pM. Isoscutellarein also inhibited the replication of influenza virus A/WSN/33 in Madin-Darby bovine kidney cells with 50
UR  - https://drive.google.com/file/d/16ehnJ8y8lecFpPUVVyh9l_JBUziv4xfW/view?usp=drivesdk
ER  -