Supercritical CO2 extraction of glycosides from Stevia rebaudiana leaves: Identification and optimization - Journal of Supercritical Fluids, 51(1), p.29-35, 2009 .

The aim of this work was to optimize the glycoside composition of Stevia rebaudiana leaves using supercritical fluid extraction (SFE). A Box-Behnken statistical design was used to evaluate the effect of various values of pressure (150.350 bar), temperature (40.80 .C)and concentration of ethanol-water mixture (70:30)as co-solvent (0.20


SUPERCRITICAL FLUID EXTRACTION
STEVIA REBAUDIANA
OPTIMIZATION
STEVIOSIDE
REBAUDIOSIDE A
BOX-BEHNKEN