TY  - BOOK
AU  - Labow,R.S.
AU  - Erfle,D.J.
AU  - Santerre,J.P.
TI  - Elastase-induced hvdrolvsis of synthetic solid subsrates: poly(ester-urea-urethane)and poly(ether-urea-urethane)
KW  - POLY(URETHANE)S
KW  - BIODEGRADATION
KW  - NEUTROPHIL
KW  - INFLAMMATORY RESPONSE
KW  - HUMAN ELASTASE
KW  - PORCINE ELASTASE
N2  - Human neutrophil elastase (HNE)and porcine pancreatic elastase (PPE)were incubated with two radiolabelled model poly(urethane)s, a poly(ester-urea-urethane)containing ['4C]toluene diisocyanate ([14C]TDl), poly(caprolactone)(PCL)and ethylenediamine (ED), and a poly(ether-urea-urethane)containing [14C]TDI, poly(tetramethylene oxide)(PTMO)and ED. Ten-fold more radioactive carbon was released when PPE was incubated with ['4C]TDI/PCLIED than when HNE was used. The PPE-induced radioactive carbon release was significantly reduced by a specific elastase inhibitor. Ten-fold less radioactive carbon was released when ['4C]TDI/PTMOIED was incubated with PPE as compared to ['4C]TDI/PCL/ED. Since neutrophils, which contain elastolytic activity, are present during the inflammatory response, the stability of biomaterials used in implanted devices may be affected
UR  - https://drive.google.com/file/d/1o8jRcW3UzhmfJzFsnUfpLJvBfA7arjas/view?usp=drivesdk
ER  -