Application of Polyhydroxyalkanoates Nanoparticles as Intracellular Sustained Drug-Release Vectors 

 -  Journal of BioMaterials Science, 21(1), p.127-140, 2010 .
<br/><br/> Polyhydroxybutyrate (PHB), co-polyesters of 3-hydroxybutyrate and 3-hydroxyhexanoate (PHBHHx), and polylactic acid (PLA)were used to prepare nanoparticles with average sizes of 160, 250 and 150 nm, respectively. A lipid-soluble colorant, rhodamine B isothiocyanate (RBITC), was employed to study drug-release behaviors from these nanoparticles. A high RBITC drug-loading efficiency of over 75 
<br/><br/><label>Subjects--Topical Terms: </label><br/>POLYHYDROXYALKANOATES<br/>PHB<br/>NANOPARTICLES<br/>DRUG DELIVERY<br/>SUSTAINED RELEASE<br/>INTRACELLULAR DRUG RELEASE<br/>MACROPHAGE