TY  - BOOK
AU  - Bokesch,H.R.
AU  - Wamiru,A.
AU  - Le Grice,S.
AU  - Beutler,J.A.
AU  - Mckee,T.C.
AU  - Mcmahon,J.B.
TI  - HIV-1 Ribonuclease H Inhibitory Phenolic Glycosides from Eugenia hyemalis
N2  - Three new galloyl arbutins, hyemalosides A-C (1-3), along with nine known compounds were isolated from the evergreen tree Eugenia hyemalis. The structures of compounds 1-3 were determined by analysis of NMR and MS data. Compounds 1-3 inhibited HIV-1 RNase H in Vitro with IC50 values of 1.46, >18, and 1.19 ìM, respectively. However, in a XTT-based cell viability assay using the human T-cell line CEM-SS infected with HIV-1RT, none of the compounds inhibited the cytopathic effect of HIV-1 infection at the highest dose tested (20 ìg/mL)
UR  - https://drive.google.com/file/d/1OlrTbWnZZaZPVE9V3X6zBg3ocNbGWwzI/view?usp=drivesdk
ER  -