TY  - BOOK
AU  - Gutiérrez,R.M.P.
AU  - Ramirez,A.M.
TI  - Hypoglycemic effects of sesquiterpene lactones from Byrsonima crassifolia
KW  - GUAIANOLIDES
KW  - ANTIDIABETIC
KW  - HYPERLIPIDEMIA
KW  - BYRSONIMA CRASSIFOLIA
N2  - The novel dimeric guaianolides sesquiterpene lactone Byrsoninas A and B from seed hexane extract of Byrsonima crassifolia were identified. Streptozotocin-induced mildly diabetic and severely diabetic mice were treated with these oral administrations at a dosage of 20 mg/kg of body weight per day for 30 days. Also the protective effect in vitro in RIN-5F cells against oxidative stress was investigated and TNF-? and IL-6 levels were measured. Both Byrsonina types reduced blood glucose, cholesterol, triglyceride, lipoprotein, and transaminase levels and increased HDL-cholesterol, antioxidant enzymes, and TBARS-reactive substance levels. Byrsoninas A and B both improved this glucose metabolism by reducing insulin resistance and by stimulating insulin production due to protection effect for pancreatic ?-cells against oxidative stress, lipid abnormalities were reduced and, chronic inflammation responses were alleviated producing a hepatoprotective role
UR  - https://drive.google.com/open?id=1hxvRSm9ZpMYC7CO_cgkFDXjWu-EQ3dZL&usp=drive_copy
ER  -