TY  - BOOK
AU  - Shah,B.A.
AU  - Kaur,R.
AU  - Gupta,P.
AU  - Kumar,A.
AU  - Sethi,V.K.
AU  - Andotra,S.S.
AU  - Singh,J.
AU  - Singh,J.
AU  - Taneja,S.C.
TI  - Structure-activity relationship (SAR)of parthenin analogues with pro-apoptotic activity: Development of novel anti-cancer leads
KW  - CYTOTOXICITY
KW  - APOPTOSIS
KW  - TOPOISOMERASE-II
KW  - TELOMERASE
KW  - SAR
KW  - PARTHENIN
N2  - Analogues of parthenin were synthesized by substitutions at different reaction centres to establish a structure-activity relationship (SAR). Some of the molecules have displayed significant cytotoxicity in human cervical carcinoma (HeLa)and human myeloid leukemia (HL-60)cells. A few of the compounds also induced apoptosis in HL-60 cells measured in terms of sub-Go/G1 DNA fraction. Also one of the lead molecules has been shown to be the inhibitor of both telomerase and topoisomerase-II
UR  - https://drive.google.com/file/d/1npSfPkTsDm20z3wr4KuqSBTBH-xCQRuB/view?usp=drivesdk
ER  -