Nanoparticle Formulation for Controlled Release of Capsaicin 

 -  Journal of NanoScience and Nanotechnology, 11(5), p.4586-4591, 2011 .
<br/><br/> Capsaicin might be an effective pharmacological agent for the treatment of discogenic back pain due to its effect on pain control neuronal degeneration. Therefore, capsaicin-loaded nano- and micro-particles for sustained release were formulated by nano-precipitation or oil-in-water single emulsion solvent evaporation/extraction method. First, the capsaicin-loaded PLGA nanoparticles were prepared by nano-precipitation method. By increasing the volume of oil-water ratio from 1:2 to 1:5, slight changes in size from 162±3 nm to 153±3 nm and in drug loading efficiency from 25 
<br/><br/><label>Subjects--Topical Terms: </label><br/>CAPSAICIN<br/>CONTROLLED RELEASE<br/>PLLA<br/>NANOPARTICLE