Omphalotin, A New Cyclic Peptide with Potent Nematicidal Activity from Omphalotus Olearius II. Isolation and Structure Determination 

 -  Natural Product Letters, 10(1), p.33-38, 1997 .
<br/><br/> The structure of the potent nematicide omphalotin, isolated from the mycelia of the basidiomycete Omphalotus olearius, was determined by spectroscopic techniques. Omphalotin is a cyclic dodecapeptide consisting of 3 glycine, 5 valine, 3 isoleucine and 1 tryptophane, and 9 of the 12 a-nitrogens are methylated. HMBC and NOESY correlations between the N-methyl groups and the a-carbonda-hydrogens established the sequence of amino acids. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>OMPHALOTUS OLEARIUS<br/>OMPHALOTIN<br/>CYCLOPEPTIDE<br/>STRUCTURE DETERMINATION