Omphalotin, A New Cyclic Peptide with Potent Nematicidal Activity from Omphalotus Olearius I. Fermentation and Biological Activity 

 -  Natural Product Letters, 10, p.25-32, 1997 .
<br/><br/> Omphalotin (l), a new cyclic peptide possessing strong and selective nematicidal activity against the plant pathogenic Meloidogyne incognita, was isolated from cultures of the basidiomycete Omphalotus olearius together with the antibiotic sesquiterpene illudin M (2)and the inactive 3-(3-indolyl)-Nmethylpropanamide (3). Omphalotin (1)is only weakly active against the saprophytic nematode Caenorhabditis elegans, it is weakly cytotoxic at 100 pg/ml but shows no phytotoxic, antibacterial or antifungal activities. The fermentation of 0. olearius and the production of the metabolites as well as the evaluation of their biological activities are reported. 
<br/><br/><label>Subjects--Topical Terms: </label><br/>OMPHALOTUS OLEARIUS<br/>OMPHALOTIN<br/>CYCLOPEPTIDE<br/>3-(3-INDOLYL)-NMETHYLPROPANAMIDE<br/>NEMATICIDAL<br/>MELOIDOGYNE INCOGNITA<br/>CAENORHABDITIS ELEGANS